What is a VDR?

18-10-2023 | Property Development


Virtual Data Rooms (VDRs) are secure and reliable ways to access confidential documents in business transactions. VDRs can be used to conduct due diligence during mergers and acquisitions, and they assist companies in organizing and share important documents with investors and other stakeholders. VDRs can also be used to store and manage contracts, invoices and other documents that are required for legal purposes such as estate planning and litigation.

Members should examine their current procedures and equipment installed on their vessels that have VDR/SVR installed. It is also advisable to to consider changing and upgrading the equipment that is outdated or do not meet minimum safety requirements.

The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D), binds to the vitamin D receptor (VDR) and retinoid X receptor (RXR) to form heterodimers that act on gene promoter regions known as vitamin D response elements. These genes regulate the expression of proteins that play a role in a myriad of physiological processes.

The VDR is found in neurons as well as a subset of glial cells that are part of the brain. In the hippocampal cells of the rat primary, immunoreactivity for VDR was observed in the oligodendrocytes. The VDR is also present in human neuroblastoma as well as astrocytes. The treatment of HL-60 leukemia cell lines by 1,25(OH2)2D3 led to monocyte-like differentiation as well as increased VDR levels. This effect was inhibited by inhibitors of the PI3K and MAPK pathways. In addition, VDR expression was increased in oligodendrocytes treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce megakaryoblastic leukemia cell maturation.


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